Mikkel Heide Schierup

Mikkel Heide Schierup
Position:
Professor
Field:
Molecular population genetics
and evolution
Office:
1110.320
Postal address:
Bioinformatics Research Center
Aarhus University, Building 1110,
C. F. Moellers Alle
DK-8000 Aarhus C, Denmark
Phone:
+45 89423231
Mobile.:
+45 27782889
Secretary.:
+45 89423100
Fax:
+45 89423077
Email:
mheide at birc.au.dk


Research Interests

Population genomics and phylogenetics

Development of methods that treat molecular evolution and population genetics as part of the same process at different time scales.

  • Coalescent Hidden Markov models for investigation of discordant gene genealogies with application to the human-chimp-gorilla trio
  • HMMs for investigation of speciation processes and introgression
  • The effect of recombination on pohylogenetic analyses

Downloadable papers

Genome analysis

  • The orangutan genome
  • The gorilla genome
  • Arabidopsis lyrata, thaliana and Capsella rubella
  • 12 fungal genomes

Association mapping

Development of case-control association mapping methods that use aspects of the underlying genealogical process

  • Bayesian methods based on explicit genealogical models, e.g. GeneRecon
  • Fast heuristic methods for genome wide scans, e.g. Blossoc
  • Methods for detection of interacting variants, epistasis

Downloadable papers

Epigenetics

The effect of the organisation of the chromatin on evolutionary rates

Self-incompatibility

Molecular evolution and population genetics of sporophytic self-incompatibility

  • Population genetics modelling and test of models in Arabidopsis lyrata
  • Comparative methods for investigation of the determinants of specificity and the evolution of new specificities

Downloadable papers

Software

In connection with Schierup et al. 2000

In connection with: J. Hein, M.H. Schierup and C. Wiuf: Gene Genealogies, Variation and Evolution

In connection with Schierup et al. 2008, Genetics in press
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